Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Heiduschka, G; Erovic, BM; Pammer, J; Kotowski, U; Kaider, A; Ch Grasl, M; Thurnher, D.
Mcl-1 expression is up-regulated in malignancies of the parotid gland.
Dis Markers. 2011; 30(5):229-233
Doi: 10.3233/DMA-2011-0779
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- Leading authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic adenoma as control was constructed. Parotid gland tumor samples were immunohistochemically stained for Mcl-1 and expression intensities were assessed. Statistical analysis included correlation to patients' clinical data and comparison of malignancies to the adenoma. All malignancies had significantly higher expression of Mcl-1 than the pleomorphic adenomas. The intensity, however, had no significant correlation to overall survival. Our immunohistochemical findings indicate that parotid gland malignancies produce high levels of Mcl-1 protein. Therefore, Mcl-1 might serve as a predictive co-marker in tumors of the parotid gland.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - metabolism
- Adenoma - pathology
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - metabolism
- Biopsy -
- Carcinoma - metabolism
- Carcinoma - pathology
- Case-Control Studies -
- Data Interpretation, Statistical -
- Female -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Immunohistochemistry - methods
- Male -
- Middle Aged -
- Myeloid Cell Leukemia Sequence 1 Protein -
- Parotid Neoplasms - metabolism
- Parotid Neoplasms - pathology
- Proto-Oncogene Proteins c-bcl-2 - metabolism
- Retrospective Studies -
- Up-Regulation -
- Young Adult -
- Find related publications in this database (Keywords)
- Mcl-1
- cancer
- parotid
- salivary gland
- head and neck