Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneider, S; Thurnher, D; Kloimstein, P; Leitner, V; Petzelbauer, P; Pammer, J; Brunner, M; Erovic, BM.
Expression of the Sonic hedgehog pathway in squamous cell carcinoma of the skin and the mucosa of the head and neck.
Head Neck. 2011; 33(2):244-250
Doi: 10.1002/hed.21437
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Activation of the hedgehog pathway may contribute to carcinogenesis. This study characterizes the expression pattern in squamous cell carcinoma of the skin and the head and neck. Tissue microarrays were constructed with samples of squamous cell carcinoma of the skin and the head and neck. All tissue samples were immunohistochemically stained for 7 Hedgehog pathway molecules. Significant (p < .0001) overexpression of all evaluated molecules could be observed in the tumor samples compared with healthy control tissues. Expression of Gli-2 showed significant upregulation and that of Smoothened and Patched significant downregulation in head and neck compared with skin carcinoma. High expression of Sonic hedgehog correlates significantly (p = .001) with poor overall survival in patients with head and neck cancer. Hedgehog signaling is differentially regulated in squamous cell carcinomas of the skin and the head and neck. Sonic hedgehog expression may serve as a prognostic factor in patients with head and neck cancer. Copyright © 2010 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - genetics
- Biomarkers, Tumor - metabolism
- Carcinoma, Squamous Cell - genetics
- Carcinoma, Squamous Cell - metabolism
- Carcinoma, Squamous Cell - pathology
- Down-Regulation -
- Female -
- Gene Expression Regulation, Neoplastic -
- Head and Neck Neoplasms - genetics
- Head and Neck Neoplasms - metabolism
- Head and Neck Neoplasms - pathology
- Hedgehog Proteins - genetics
- Hedgehog Proteins - metabolism
- Humans -
- Kruppel-Like Transcription Factors - metabolism
- Male -
- Middle Aged -
- Mutation -
- Nuclear Proteins - metabolism
- Predictive Value of Tests -
- Prognosis -
- Protein Array Analysis -
- Signal Transduction -
- Skin Neoplasms - genetics
- Skin Neoplasms - metabolism
- Skin Neoplasms - pathology
- Survival Analysis -
- Up-Regulation -
- Find related publications in this database (Keywords)
- Sonic hedgehog
- squamous cell carcinoma
- head and neck
- skin
- tissue microarray