Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lill, C; Kornek, G; Bachtiary, B; Selzer, E; Schopper, C; Mittlboeck, M; Burian, M; Wrba, F; Thurnher, D.
Survival of patients with HPV-positive oropharyngeal cancer after radiochemotherapy is significantly enhanced.
Wien Klin Wochenschr. 2011; 123(7-8):215-221
Doi: 10.1007/s00508-011-1553-z
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- The purpose of this study was to evaluate the incidence and clinical significance of HPV (Human papilloma virus) infection in patients with head and neck cancer who had received radiotherapy in Eastern Austria. 88 patients with head and neck cancer including 26 patients with oral cavity cancer, 45 patients with oropharyngeal cancer, seven patients with laryngeal carcinoma and ten patients with carcinoma of the hypopharynx were screened for high risk HPV by immunohistochemistry, PCR (Polymerase Chain Reaction) and in-situ hybridization. 29 out of 45 patients with a squamous cell carcinoma of the oropharynx received radiotherapy alone, radiotherapy in combination with cisplatin or cetuximab. Of the investigated 29 patients with oropharyngeal cancer receiving conservative treatment, 11 had a HPV-positive and 18 a HPV-negative tumor. Patients received radiation ± cisplatin or cetuximab, where the HPV-positive patients had a significant better response to treatment and overall survival (p = 0.015) as well as disease-free survival (p = 0.001) after therapy. Patients with oropharyngeal carcinoma and a positive HPV status respond considerably better to radiochemotherapy than patients with HPV-negative tumors. HPV screening is a simple procedure and can easily be implemented in routine pathology investigations and should be included in standard operational procedures for the diagnosis and therapy of head and neck cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Chemotherapy, Adjuvant - mortality
- Comorbidity -
- Female -
- Humans -
- Male -
- Middle Aged -
- Oropharyngeal Neoplasms - mortality
- Oropharyngeal Neoplasms - therapy
- Papillomavirus Infections - mortality
- Papillomavirus Infections - therapy
- Prevalence -
- Radiotherapy, Adjuvant - mortality
- Risk Assessment -
- Risk Factors -
- Survival Analysis -
- Survival Rate -
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- Oropharyngeal cancer
- HPV
- radiochemotherapy