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Lill, C; Schneider, S; Pammer, J; Loewe, R; Gedlicka, W; Houben, R; Heiduschka, G; Brunner, M; Thurnher, D.
Significant correlation of peptidyl-prolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients.
Head Neck. 2011; 33(9):1294-1300 Doi: 10.1002/hed.21596
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Leading authors Med Uni Graz: Thurnher Dietmar
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Abstract:: An overexpression of PIN1, the peptidyl-prolyl cis-trans isomerase, might cause cell cycle arrest and growth inhibition by binding to the p53 protein, a process leading to p53 stabilization. The rationale of this retrospective analysis was to evaluate the expression pattern of PIN1 in Merkel cell carcinomas (MCCs) and its suitability as a prognostic factor. Samples of 27 MCCs were immunhistochemically stained for PIN1 expression and correlated with overall and disease-free survival of patients. All samples expressed PIN1. We showed a significantly better overall survival in patients with an overexpression of PIN1 than in patients with a weak PIN1 expression (p = .031), but expression was not significant for disease-free survival (p = .821). The 5-year overall survival rate was 14.4% in patients with weak and 50.9% in patients with overexpression of PIN1. PIN1 seems to be a prognostic factor for a better overall survival rate of patients with MCC. Copyright © 2010 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged, 80 and over -; Carcinoma, Merkel Cell - enzymology; Carcinoma, Merkel Cell - mortality; Carcinoma, Merkel Cell - pathology; Female -; Humans -; Immunohistochemistry -; Male -; Middle Aged -; NIMA-Interacting Peptidylprolyl Isomerase -; Peptidylprolyl Isomerase - metabolism; Prognosis -; Retrospective Studies -; Skin Neoplasms - enzymology; Skin Neoplasms - mortality; Skin Neoplasms - pathology; Survival Analysis -
Find related publications in this database (Keywords): Merkel cell carcinoma; prognostic factor; PIN1