Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lill, C; Schneider, S; Pammer, J; Loewe, R; Gedlicka, W; Houben, R; Heiduschka, G; Brunner, M; Thurnher, D.
Significant correlation of peptidyl-prolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients.
Head Neck. 2011; 33(9):1294-1300
Doi: 10.1002/hed.21596
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- An overexpression of PIN1, the peptidyl-prolyl cis-trans isomerase, might cause cell cycle arrest and growth inhibition by binding to the p53 protein, a process leading to p53 stabilization. The rationale of this retrospective analysis was to evaluate the expression pattern of PIN1 in Merkel cell carcinomas (MCCs) and its suitability as a prognostic factor. Samples of 27 MCCs were immunhistochemically stained for PIN1 expression and correlated with overall and disease-free survival of patients. All samples expressed PIN1. We showed a significantly better overall survival in patients with an overexpression of PIN1 than in patients with a weak PIN1 expression (p = .031), but expression was not significant for disease-free survival (p = .821). The 5-year overall survival rate was 14.4% in patients with weak and 50.9% in patients with overexpression of PIN1. PIN1 seems to be a prognostic factor for a better overall survival rate of patients with MCC. Copyright © 2010 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Carcinoma, Merkel Cell - enzymology
- Carcinoma, Merkel Cell - mortality
- Carcinoma, Merkel Cell - pathology
- Female -
- Humans -
- Immunohistochemistry -
- Male -
- Middle Aged -
- NIMA-Interacting Peptidylprolyl Isomerase -
- Peptidylprolyl Isomerase - metabolism
- Prognosis -
- Retrospective Studies -
- Skin Neoplasms - enzymology
- Skin Neoplasms - mortality
- Skin Neoplasms - pathology
- Survival Analysis -
- Find related publications in this database (Keywords)
- Merkel cell carcinoma
- prognostic factor
- PIN1