Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Funk, GC; Lindner, G; Druml, W; Metnitz, B; Schwarz, C; Bauer, P; Metnitz, PG.
Incidence and prognosis of dysnatremias present on ICU admission.
Intensive Care Med. 2010; 36(2):304-311
Doi: 10.1007/s00134-009-1692-0
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Metnitz Philipp
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- Abstract:
- Dysnatremias are common in patients admitted to the intensive care unit (ICU). Whether the presence of disorders of sodium balance on ICU admission is independently associated with excess mortality is unknown. We hypothesized that dysnatremias at the time of ICU admission are independent risk factors for increased mortality in critically ill patients. We conducted a retrospective study in 77 medical, surgical, and mixed ICUs in Austria, with a database of 151,486 adults admitted consecutively over a period of 10 years (1998-2007). Most patients (114,170, 75.4%) had normal sodium levels (135 < or = Na < or = 145 mmol/L) on ICU admission. The frequencies of borderline (130 < or = Na < 135 mmol/L), mild (125 < or = Na < 130 mmol/L), and severe hyponatremia (Na < 125 mmol/L) were 13.8%, 2.7%, and 1.2%, respectively. The frequencies of borderline (145 < Na < or = 150 mmol/L), mild (150 < Na < or = 155 mmol/L), and severe hypernatremia (Na > 155 mmol/L) were 5.1%, 1.2%, and 0.6%, respectively. All types and grades of dysnatremia were associated with increased raw and risk-adjusted hospital mortality ratios. Multiple logistic regression analysis showed an independent mortality risk rising with increasing severity of both hyponatremia and hypernatremia. Odds ratios and 95% confidence interval (CI) for borderline, mild, and severe hyponatremia were 1.32 (1.25-1.39), 1.89 (1.71-2.09), and 1.81 (1.56-2.10), respectively. Odds ratios and 95% CI for borderline, mild, and severe hypernatremia were 1.48 (1.36-1.61), 2.32 (1.98-2.73), and 3.64 (2.88-4.61), respectively. Our results suggest that both hypo- and hypernatremia present on admission to the ICU are independent risk factors for poor prognosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Humans -
- Hypernatremia - epidemiology
- Hypernatremia - physiopathology
- Hyponatremia - epidemiology
- Hyponatremia - physiopathology
- Incidence -
- Intensive Care Units - statistics & numerical data
- Patient Admission - statistics & numerical data
- Prognosis -
- Retrospective Studies -
- Severity of Illness Index -
- Young Adult -
- Find related publications in this database (Keywords)
- Hyponatremia
- Hypernatremia
- Sodium
- Outcome
- Epidemiology