Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Edelmann, F; Holzendorf, V; Wachter, R; Nolte, K; Schmidt, AG; Kraigher-Krainer, E; Duvinage, A; Unkelbach, I; Düngen, HD; Tschöpe, C; Herrmann-Lingen, C; Halle, M; Hasenfuss, G; Gelbrich, G; Stough, WG; Pieske, BM.
Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial.
Eur J Heart Fail. 2015; 17(2):214-223
Doi: 10.1002/ejhf.203
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- Co-Autor*innen der Med Uni Graz
- Kraigher-Krainer Elisabeth
- Pieske Burkert Mathias
- Schmidt Albrecht
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- Abstract:
- Galectin-3 is a marker of myocardial fibrosis and mediates aldosterone-induced cardiovascular inflammation and fibrosis. Characteristics of galectin-3 and its response to spironolactone have not been evaluated in heart failure with preserved ejection fraction (HFpEF). The aim of this study was to determine the association between galectin-3 levels and patient characteristics in HFpEF; to evaluate the interaction between spironolactone and galectin-3 levels; and to assess the association between galectin-3 and clinical outcomes. Aldo-DHF investigated spironolactone 25 mg once daily vs. placebo for 12 months in patients with NYHA class II-III, LVEF ≥50%, grade ≥ I diastolic dysfunction, and peakVO2 ≤ 25 mL/kg/min. Galectin-3 levels were obtained at baseline, and at 6 and 12 months. The association between baseline galectin-3, change in galectin-3, and all-cause death or hospitalization was evaluated, and the interaction between galectin-3 and treatment was assessed. Median baseline galectin-3 was 12.1 ng/mL. After multivariable adjustment, baseline galectin-3 inversely correlated with peak VO2 (P = 0.021), 6 min walk distance (P = 0.002), and Short Form 36 (SF-36) physical functioning (P = 0.001), and directly correlated with NYHA class (P = 0.007). Baseline NT-proBNP correlated with E/e' velocity ratio (P ≤ 0.001), left atrial volume index (P < 0.001), and LV mass index (P = 0.009). Increasing galectin-3 at 6 or 12 months was associated with all-cause death or hospitalization independent of treatment arm [hazard ratio (HR) 3.319, 95% confidence interval (CI) 1.214-9.07, P = 0.019] and NT-proBNP (HR 3.127, 95% CI 1.144-8.549, P = 0.026). Spironolactone did not influence galectin-3 levels. Galectin-3 levels are modestly elevated in patients with stable HFpEF and relate to functional performance and quality of life. Increasing galectin-3 was associated with worse outcome, independent of treatment or NT-proBNP. © 2014 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Diuretics - therapeutic use
- Female -
- Galectin 3 - blood
- Heart Failure - blood Heart Failure - drug therapy
- Humans -
- Male -
- Middle Aged -
- Spironolactone - therapeutic use
- Stroke Volume - physiology
- Ventricular Function, Left - drug effects
- Ventricular Remodeling -
- Find related publications in this database (Keywords)
- Galectin-3
- Heart failure
- Diastolic
- Mortality
- Morbidity
- Spironolactone