Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P.
Involvement of nitric oxide in the substance P-induced inhibition of intestinal peristalsis.
NEUROREPORT 1997 8: 2857-2860.
Doi: 10.1097/00001756-199709080-00011
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- Although considered as an intestinal motor stimulant, substance P can inhibit intestinal peristalsis via stimulation of tachykinin NK1 receptors. Since NK1 receptors are present on enteric nitrergic neurones, the contribution of nitric oxide (NO) to the peristaltic motor inhibition caused by tachykinins was examined in luminally perfused segments of isolated guinea-pig ileum. Substance P (100 nM) and the NK1 receptor agonist substance P methyl ester (100 nM) increased the intraluminal pressure threshold at which peristaltic contractions were elicited. This inhibitory influence on peristalsis was prevented by the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (300 microM) in an enantiomer-selective manner. It is concluded that the substance P/NK1 receptor-mediated depression of intestinal peristalsis involves inhibitory motor pathways utilizing NO as a transmitter.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Enzyme Inhibitors - pharmacology
- Female - pharmacology
- Guinea Pigs - pharmacology
- Ileum - drug effects
- In Vitro - drug effects
- Male - drug effects
- NG-Nitroarginine Methyl Ester - pharmacology
- Nitric Oxide - physiology
- Peristalsis - drug effects
- Receptors, Neurokinin-1 - agonists
- Research Support, Non-U.S. Gov't - agonists
- Stereoisomerism - agonists
- Substance P - analogs and derivatives
- Find related publications in this database (Keywords)
- Enteric Nervous System
- Enteric Nitrergic Neurons
- Guinea-Pig
- Nitric Oxide
- Nk1 Receptors
- Peristalsis
- Small Intestine
- Substance P
- Substance P Methyl Ester
- Tachykinins