Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomaschitz, A; Pilz, S; Rus-Machan, J; Meinitzer, A; Brandenburg, VM; Scharnagl, H; Kapl, M; Grammer, T; Ritz, E; Horina, JH; Kleber, ME; Pieske, B; Kraigher-Krainer, E; Hartaigh, BÓ; Toplak, H; van Ballegooijen, AJ; Amrein, K; Fahrleitner-Pammer, A; März, W.
Interrelated aldosterone and parathyroid hormone mutually modify cardiovascular mortality risk.
Int J Cardiol. 2015; 184(9):710-716
Doi: 10.1016/j.ijcard.2015.03.062
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Tomaschitz Andreas
- Co-Autor*innen der Med Uni Graz
- Amrein Karin
- Fahrleitner-Pammer Astrid
- Horina Joerg
- Kapl Martin
- Kraigher-Krainer Elisabeth
- März Winfried
- Meinitzer Andreas
- Pieske Burkert Mathias
- Scharnagl Hubert
- Toplak Hermann
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- Abstract:
- Inappropriate aldosterone and parathyroid hormone (PTH) secretion is associated with increased cardiovascular risk. Accumulating evidence suggests bidirectional interplay between aldosterone and PTH. We evaluated the cross-sectional relationship between plasma aldosterone concentration (PAC), aldosterone to renin ratio (ARR) and PTH and subsequently tested whether the interaction between PAC and PTH modified the risk of cardiovascular death. PAC [78.0 (48.0-123.0) pg/mL], ARR [6.4 (2.9-12.9) pg/mL/pg/mL] and PTH concentration [median: 29.0 (22.0-40.0) pg/mL] were measured in 3074 patients (mean age: 62.5 ± 10.6 years; 30.3% women) referred to coronary angiography in a tertiary care center in Southwest Germany. Using multiple linear regression analysis, PAC and ARR emerged as an independent predictor of higher PTH concentrations (β=0.12 and 0.21, P<0.001 for both) irrespective of intake of antihypertensive treatment, 25(OH)D, kidney function, serum calcium, phosphate, magnesium, cortisol, NT-pro-BNP, soluble α-klotho and FGF-23 concentration. After a median follow-up of 9.9 years, 512 (16.7%) participants had died due to fatal cardiovascular events. Multivariate Cox proportional hazard analysis revealed that both PAC and PTH were independently associated with cardiovascular mortality, with a potential synergistic interaction (P=0.028). PAC and PTH are exclusively associated with cardiovascular death in subjects with PTH and PAC concentrations above the median, respectively (PAC: HR per log SD: 1.14; 95% CI 1.02-1.29; P=0.026; PTH: HR per log SD: 1.18; 95% CI 1.02-1.37; P=0.031). Higher PAC and ARR were independently associated with PTH. PAC was independently related to incident cardiovascular mortality exclusively in patients with elevated PTH and vice versa. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aldosterone - blood
- Biomarkers - blood
- Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis
- Cross-Sectional Studies -
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Parathyroid Hormone - blood
- Risk Factors -
- Find related publications in this database (Keywords)
- Aldosterone
- Parathyroid hormone
- Cardiovascular mortality