Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Srimathveeravalli, G; Silk, M; Wimmer, T; Monette, S; Kimm, S; Maybody, M; Solomon, SB; Coleman, J; Durack, JC.
Feasibility of catheter-directed intraluminal irreversible electroporation of porcine ureter and acute outcomes in response to increasing energy delivery.
J Vasc Interv Radiol. 2015; 26(7):1059-1066
Doi: 10.1016/j.jvir.2015.01.020
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- Co-Autor*innen der Med Uni Graz
- Wimmer Thomas
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- Abstract:
- To evaluate the feasibility of focal intraluminal irreversible electroporation (IRE) in the ureter with a novel electrode catheter and to study the treatment effects in response to increasing pulse strength. Five IRE treatment settings were each evaluated twice for the ablation of normal ureter in 5 Yorkshire pigs (n = 1-4 ablations per animal; total of 10 ablations) with the use of a prototype device under ultrasound and fluoroscopic guidance. Animals received unilateral or bilateral treatment, limited to a maximum of 2 ablations in any 1 ureter. Treatment was delivered with increasing pulse strength (from 1,000 V to 3,000 V in increments of 500 V) while keeping the pulse duration (100 μs) and number of pulses (n = 90) constant. Ureter patency was assessed with antegrade ureteropyelography immediately following treatment. Animals were euthanized within 4 hours after treatment, and treated urinary tract was harvested for histopathologic analysis with hematoxylin and eosin and Masson trichrome stains. IRE was successfully performed in all animals, without evidence of ureteral perforation. Hematoxylin and eosin analysis of IRE treatments demonstrated full-thickness ablation at higher field strengths (mucosa to the adventitia). Masson trichrome stains showed preservation of connective tissue at all field strengths. Intraluminal catheter-directed IRE ablation is feasible and produces full-thickness ablation of normal ureters. There was no evidence of lumen perforation even at the maximum voltages evaluated. Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Catheter Ablation - adverse effects
- Catheter Ablation - instrumentation
- Catheter Ablation - methods
- Catheters -
- Electroporation - instrumentation
- Equipment Design -
- Feasibility Studies -
- Female -
- Microelectrodes -
- Models, Animal -
- Necrosis -
- Radiography, Interventional -
- Swine -
- Ureter - diagnostic imaging
- Ureter - pathology
- Ureter - surgery