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Selected Publication:
Schauenstein, K; Csordas, A; Krömer, G; Dietrich, H; Wick, G.
In-vivo treatment with 5-azacytidine causes degeneration of central lymphatic organs and induces autoimmune disease in the chicken.
Int J Exp Pathol. 1991; 72(3):311-318
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- Schauenstein Konrad
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- Abstract:
- In-vitro evidence suggests that DNA methylation may be involved in the development of forbidden immune responses that can result in autoimmune disease. In the present study we examined in-vivo effects of 5-azacytidine (5-azaC), a substance that inhibits DNA methylation, on the immune system and the occurrence of a spontaneous autoimmune disease in the chicken model. We found that (1) treatment of young normal chickens with 1.0 mg/kg 5-azaC on 7 consecutive days caused a rapid degeneration of the central lymphoid organs thymus and bursa; (2) this regimen with 5-azaC apparently inhibited B cell maturation, as the frequency of cytoplasmic Ig+ plasma cells in the bone marrow was found to be significantly reduced, whereas the total number of bone marrow cells was unchanged; and (3) a chronic low-dose (0.5 and 1.0 mg/kg) application of 5-azaC through 6 weeks was found to significantly enhance the spontaneous autoimmune thyroiditis in newly hatched chickens of the Cornell C strain, as determined by anti-thyroglobulin autoantibody titres and histological analysis of thyroid gland infiltration. The possible implications of these data for the generation of pathogenic autoimmune responses are discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoimmune Diseases - chemically induced
- Azacitidine - toxicity
- Body Weight - drug effects
- Bone Marrow - drug effects
- Chickens - drug effects
- Lymphatic Diseases - chemically induced
- Lymphoid Tissue - drug effects
- Organ Size - drug effects
- Organ Specificity - drug effects
- Find related publications in this database (Keywords)
- DNA Methylation
- 5-Azacytidine
- Thymus
- Bursa
- Autoimmune Disease
- Obese Strain Chickens