Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Valko, PO; Gavrilov, YV; Yamamoto, M; Finn, K; Reddy, H; Haybaeck, J; Weis, S; Scammell, TE; Baumann, CR.
Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury.
Ann Neurol. 2015; 77(1):177-182
Doi: 10.1002/ana.24298
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- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here, we demonstrate that severe head trauma is associated with a marked loss (41%) of histaminergic neurons. Reduced histamine signaling may contribute to increased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma or other conditions. © 2014 American Neurological Association.
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- Aged -
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- Brain Injuries - pathology
- Female -
- Glial Fibrillary Acidic Protein - metabolism
- Histamine - metabolism
- Histidine Decarboxylase - metabolism
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- Hypothalamic Area, Lateral - pathology
- Hypothalamic Hormones - metabolism
- Hypothalamus - pathology
- Intracellular Signaling Peptides and Proteins - metabolism
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- Melanins - metabolism
- Neurons - metabolism
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- Neuropeptides - metabolism
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- Pituitary Hormones - metabolism
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