Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ediebah, DE; Coens, C; Zikos, E; Quinten, C; Ringash, J; King, MT; Schmucker von Koch, J; Gotay, C; Greimel, E; Flechtner, H; Weis, J; Reeve, BB; Smit, EF; Taphoorn, MJ; Bottomley, A.
Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial.
Br J Cancer. 2014; 110(10):2427-2433
Doi: 10.1038/bjc.2014.208
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greimel Elfriede Renate
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Little is known about whether changes in health-related quality of life (HRQoL) scores from baseline during treatment also predict survival, which we aim to investigate in this study. We analysed data from 391 advanced non-small-cell lung cancer (NSCLC) patients enrolled in the EORTC 08975 study, which compared palliative chemotherapy regimens. HRQoL was assessed at baseline and after each chemotherapy cycle using the EORTC QLQ-C30 and QLQ-LC13. The prognostic significance of HRQoL scores at baseline and their changes over time was assessed with Cox regression, after adjusting for clinical and socio-demographic variables. After controlling for covariates, every 10-point increase in baseline pain and dysphagia was associated with 11% and 12% increased risk of death with hazard ratios (HRs) of 1.11 and 1.12, respectively. Every 10-point improvement of physical function at baseline (HR=0.93) was associated with 7% lower risk of death. Every 10-point increase in pain (HR=1.08) was associated with 8% increased risk of death at cycle 1. Every 10-point increase in social function (HR=0.91) at cycle 2 was associated with 9% lower risk of death. Our findings suggest that changes in HRQoL scores from baseline during treatment, as measured on subscales of the EORTC QLQ-C30 and QLQ-LC13, are significant prognostic factors for survival.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Carcinoma, Non-Small-Cell Lung - drug therapy
- Carcinoma, Non-Small-Cell Lung - mortality
- Carcinoma, Non-Small-Cell Lung - psychology
- Cisplatin - administration & dosage
- Clinical Trials, Phase III as Topic - statistics & numerical data
- Deglutition Disorders - epidemiology
- Deglutition Disorders - etiology
- Deoxycytidine - administration & dosage
- Deoxycytidine - analogs & derivatives
- Humans -
- Interpersonal Relations -
- Lung Neoplasms - drug therapy
- Lung Neoplasms - mortality
- Lung Neoplasms - psychology
- Multicenter Studies as Topic - statistics & numerical data
- Nausea - epidemiology
- Nausea - etiology
- Paclitaxel - administration & dosage
- Pain - epidemiology
- Pain - etiology
- Palliative Care -
- Prognosis -
- Proportional Hazards Models -
- Quality of Life -
- Randomized Controlled Trials as Topic - statistics & numerical data
- Risk -
- Severity of Illness Index -
- Surveys and Questionnaires -
- Survival Analysis -
- Find related publications in this database (Keywords)
- lung cancer
- health-related quality of life
- patient-reported outcomes
- prognostic factors