Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chauhan, G; Adams, HHH; Bis, JC; Weinstein, G; Yu, L; Töglhofer, AM; Smith, AV; van der Lee, SJ; Gottesman, RF; Thomson, R; Wang, J; Yang, Q; Niessen, WJ; Lopez, OL; Becker, JT; Phan, TG; Beare, RJ; Arfanakis, K; Fleischman, D; Vernooij, MW; Mazoyer, B; Schmidt, H; Srikanth, V; Knopman, DS; Jack, CR; Amouyel, P; Hofman, A; DeCarli, C; Tzourio, C; van Duijn, CM; Bennett, DA; Schmidt, R; Longstreth, WT; Mosley, TH; Fornage, M; Launer, LJ; Seshadri, S; Ikram, MA; Debette, S.
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.
Neurobiol Aging. 2015; 36(4):1765.e7-1761765
Doi: 10.1016/j.neurobiolaging.2014.12.028
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- Co-Autor*innen der Med Uni Graz
- Birkl-Töglhofer Anna Maria
- Schmidt Helena
- Schmidt Reinhold
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- Abstract:
- Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N = 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (p = 0.0006) and BIN1 with HV (p = 0.00089). A weighted AD genetic risk score was associated with smaller HV (beta ± SE = -0.047 ± 0.013, p = 0.00041), even after excluding the APOE locus (p = 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons. Copyright © 2015 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging - genetics
- Aging - pathology
- Alleles -
- Alzheimer Disease - genetics
- Alzheimer Disease - pathology
- Apolipoproteins E - genetics
- Brain - pathology
- Female -
- Genome-Wide Association Study -
- Hippocampus - pathology
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Organ Size - genetics
- Polymorphism, Single Nucleotide -
- Risk -
- Sialic Acid Binding Ig-like Lectin 3 - genetics
- Find related publications in this database (Keywords)
- Alzheimer
- MRI-Markers
- Genetic risk score
- GWAS
- Hippocampal volume