Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pelzmann, B; Schaffer, P; Mächler, H; Rigler, B; Koidl, B.
Adenosine inhibits the L-type calcium current in human atrial myocytes.
Naunyn Schmiedebergs Arch Pharmacol. 1995; 351(3):293-297
Doi: 10.1007/BF00233249
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Pelzmann Brigitte
- Co-Autor*innen der Med Uni Graz
- Koidl Bernd
- Mächler Heinrich
- Rigler Bruno
- Schaffer Peter
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- Abstract:
- The effects of adenosine on the L-type Ca2+ current (Ica) were studied in human atrial myocytes using the whole-cell voltage clamp technique. Ica was recorded under physiological calcium concentrations (1.8 mmol/l) at 37 degrees C. Under these conditions the current density of basal Ica averaged 4.0 pA/pF. Isoprenaline (1 mumol/l) increased basal Ica to 249.7%. Adenosine (100 mumol/l) in the presence of isoprenaline (1 mumol/l) decreased Ica from the level obtained with isoprenaline to 87.5% of basal Ica. Adenosine (0.1 to 100 mumol/l) also reduced basal Ica, maximally to 64.5% of control. Activation and inactivation parameters of basal Ica were not significantly different between adenosine (100 mumol/l) and control recordings. Our results show that adenosine affects both basal and isoprenaline stimulated Ica in human atrial myocytes. Although a considerable decrease of basal Ica was seen, we conclude that the action of adenosine on L-type Ca2+ current in human atrial myocytes is mainly antiadrenergic. Both effects may contribute to the antiarrhythmic properties of adenosine.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcholine - pharmacology
- Adenosine - pharmacology
- Calcium Channel Blockers - pharmacology
- Cells, Cultured -
- Heart Atria - cytology Heart Atria - drug effects Heart Atria - metabolism
- Humans -
- Isoproterenol - pharmacology
- Membrane Potentials - drug effects
- Myocardium - cytology Myocardium - metabolism
- Patch-Clamp Techniques -
- Find related publications in this database (Keywords)
- Human Atrial Cells
- Ca2+ Current
- Adenosine
- Antiadrenergic Effect
- Isoprenaline