Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Khoschsorur, G; Tatzber, F; Freigassner, M; Tscheliessnigg, KH; Iberer, F; Lamprecht, M; Uranüs, S; Petek, W.
Inverse Correlation of Malondialdehyde (MDA) and Anti-Cu2+ Oxidized Low-Density-Lipoprotein (LDL) Immunoglobulin-G (IgG) Antibodies in Transplantation Patients
MED SCI RES 1996 24: 851-854.
Web of Science
- Führende Autor*innen der Med Uni Graz
- Khoschsorur Gholamali
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Tscheliessnigg Karlheinz
- Uranüs Selman
- Altmetrics:
- Abstract:
- Malonic dialdehyde (MDA) is one of the major aldehydes synthesised during lipid peroxidation (LPO). LPO occurs in ischaemic situations, such as surgical revascularisation, myocardial infarction, lysis and transplantation. In the latter, there is still a demand for predictive parameters for rejection and/or infection. Therefore, we measured standard parameters for transplantation monitoring, including neopterin and elastase, together with MDA levels and titres of antibodies binding to Cu2+-oxidised LDL (oLAb) to ascertain whether these parameters would give additional information on the outcome of transplantation. There was a positive correlation between MDA and neopterin in the liver transplantation patients, including one patient with fatal outcome (r=0.76, p<0.001). There were further inverse correlations between oLAb and MDA in liver (r=0.61, p<0.001) and heart transplantations (r=0.54, p<0.05). We conclude that MDA is a useful parameter for determining prognosis in transplantation patients. Therefore, MDA and oLAb measurements may be additional parameters for predicting the outcome of allograft transplantation patients.
- Find related publications in this database (Keywords)
- Malondialdehyde
- Oxidized Low-Density Lipoprotein (LDL)
- Polymorphonuclear Granulocytes (PMN) Elastase
- C-Reactive Protein
- Neopterin
- Biomarkers
- Transplantation