Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Greinix, HT; Kuzmina, Z; Weigl, R; Körmoczi, U; Rottal, A; Wolff, D; Kralj, M; Kalhs, P; Mitterbauer, M; Rabitsch, W; Edinger, M; Holler, E; Pickl, WF.
CD19+CD21low B cells and CD4+CD45RA+CD31+ T cells correlate with first diagnosis of chronic graft-versus-host disease.
Biol Blood Marrow Transplant. 2015; 21(2):250-258
Doi: 10.1016/j.bbmt.2014.11.010
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- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Chronic graft-versus-host disease (cGVHD) is a serious and frequent complication of allogeneic hematopoietic stem cell transplantation (HCT). Currently, no biomarkers for prediction and diagnosis of cGVHD are available. We performed a large prospective study focusing on noninvasive biomarkers for National Institutes of Health-defined cGVHD patients (n = 163) in comparison to time-matched HCT recipients who never experienced cGVHD (n = 64), analyzed from day 100 after HCT. In logistic regression analysis, CD19(+)CD21(low) B cells (P = .002; hazard ratio [HR], 3.31; 95% confidence interval [CI], 1.53 to 7.17) and CD4(+)CD45RA(+)CD31(+) T cells (P < .001; HR, 3.88; 95% CI, 1.88 to 7.99) assessed on day 100 after HCT were significantly associated with subsequent development of cGVHD, independent of clinical parameters. A significant association with diagnosis of cGVHD was only observed for CD19(+)CD21(low) B cells (P = .008; HR, 3.00; 95% CI, 1.33 to 6.75) and CD4(+)CD45RA(+)CD31(+) T cells (P = .017; HR, 2.80; 95% CI, 1.19 to 6.55). CD19(+)CD21(low) B cells were found to have the highest discriminatory value with an area under the receiver operating curve of .77 (95% CI, .64 to .90). Our results demonstrate that CD19(+)CD21(low) B cells and CD4(+)CD45RA(+)CD31(+) T cells are significantly elevated in patients with newly diagnosed cGVHD. Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antigens, CD - genetics
- Antigens, CD - immunology
- B-Lymphocytes - immunology
- B-Lymphocytes - pathology
- Biomarkers - analysis
- CD4-Positive T-Lymphocytes - immunology
- CD4-Positive T-Lymphocytes - pathology
- Chronic Disease -
- Female -
- Gene Expression -
- Graft vs Host Disease - diagnosis
- Graft vs Host Disease - immunology
- Graft vs Host Disease - pathology
- Hematologic Neoplasms - pathology
- Hematologic Neoplasms - therapy
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Immunophenotyping -
- Logistic Models -
- Lymphocyte Count -
- Male -
- Middle Aged -
- Prognosis -
- Prospective Studies -
- ROC Curve -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- Chronic graft-versus-host disease
- Biomarker
- B cells