Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jagasia, M; Greinix, H; Robin, M; Das-Gupta, E; Jacobs, R; Savani, BN; Engelhardt, BG; Kassim, A; Worel, N; Knobler, R; Russell, N; Socie, G.
Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid-refractory acute GVHD: a multicenter comparative analysis.
Biol Blood Marrow Transplant. 2013; 19(7): 1129-1133.
Doi: 10.1016/j.bbmt.2013.04.018
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- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- The optimal therapy for steroid-refractory (SR) acute graft-versus-host disease (aGVHD) is undefined. We studied patients with SR aGVHD, comparing extracorporeal photopheresis (ECP; n = 57) and anticytokine therapy (n = 41). In multivariate analyses, ECP, adjusted for steroid dose (odds ratio, 3.42; P = .007), and grade >II aGVHD (odds ratio, 68; P < .001) were independent predictors of response. ECP therapy, adjusted for conditioning regimen intensity and steroid dose, was associated with superior survival (hazard ratio [HR], 4.6; P = .016) in patients with SR grade II aGVHD. Grade >II aGVHD at onset of salvage therapy (HR, 9.4; P < .001) and lack of response to therapy (HR, 3.09; P = .011) were associated with inferior survival. These findings require validation in a prospective randomized study. Copyright © 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adolescent -
- Adrenal Cortex Hormones - therapeutic use
- Adult -
- Aged -
- Antineoplastic Agents - therapeutic use
- Child -
- Child, Preschool -
- Cytokines - antagonists & inhibitors Cytokines - immunology
- Drug Administration Schedule -
- Female -
- Graft vs Host Disease - immunology Graft vs Host Disease - mortality Graft vs Host Disease - pathology Graft vs Host Disease - therapy
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Male -
- Middle Aged -
- Photopheresis -
- Prognosis -
- Retrospective Studies -
- Survival Analysis -
- Transplantation Conditioning -
- Transplantation, Homologous -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Acute graft-versus-host disease
- Steroid-refractory
- Extracorporeal photopheresis
- Allogeneic hematopoietic cell transplantation