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SHR Neuro Cancer Cardio Lipid Metab Microb
Jagasia, MH; Greinix, HT; Arora, M; Williams, KM; Wolff, D; Cowen, EW; Palmer, J; Weisdorf, D; Treister, NS; Cheng, GS; Kerr, H; Stratton, P; Duarte, RF; McDonald, GB; Inamoto, Y; Vigorito, A; Arai, S; Datiles, MB; Jacobsohn, D; Heller, T; Kitko, CL; Mitchell, SA; Martin, PJ; Shulman, H; Wu, RS; Cutler, CS; Vogelsang, GB; Lee, SJ; Pavletic, SZ; Flowers, ME.
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Biol Blood Marrow Transplant. 2015; 21(3):389-401
Doi: 10.1016/j.bbmt.2014.12.001
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- Co-authors Med Uni Graz
- Greinix Hildegard
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- Abstract:
- The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies. Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers -
- Chronic Disease -
- Clinical Trials as Topic - methods
- Clinical Trials as Topic - standards
- Consensus -
- Consensus Development Conferences, NIH as Topic -
- Female -
- Graft vs Host Disease - diagnosis
- Graft vs Host Disease - metabolism
- Graft vs Host Disease - therapy
- Humans -
- Male -
- Organ Specificity -
- Practice Guidelines as Topic -
- Practice Guidelines as Topic -
- Find related publications in this database (Keywords)
- Chronic graft-versus-host disease
- National Institutes of Health
- Diagnosis
- Staging