Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brüggen, MC; Petzelbauer, P; Greinix, H; Contassot, E; Jankovic, D; French, L; Socié, G; Rabitsch, W; Kuzmina, Z; Kalhs, P; Knobler, R; Stingl, G; Stary, G.
Epidermal elafin expression is an indicator of poor prognosis in cutaneous graft-versus-host disease.
J Invest Dermatol. 2015; 135(4):999-1006
Doi: 10.1038/jid.2014.489
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Graft-versus-host disease (GVHD) remains a common and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. In the skin, GVHD can present in an acute (aGVHD), chronic lichenoid (clGVHD), or chronic sclerotic form (csGVHD). Measuring peripheral blood levels of the keratinocyte-derived protease inhibitor elafin has recently emerged as a promising tool for the diagnosis of cutaneous aGVHD. We evaluated whether the analysis of elafin expression in skin would allow distinguishing aGVHD from drug hypersensitivity rashes (DHR) and whether cutaneous elafin expression would correlate with disease severity or altered prognosis of aGVHD and clGVHD/csGVHD. Skin biopsies from aGVHD (n=22), clGVHD (n=15), csGVHD (n=7), and DHR (n=10) patients were collected and epidermal elafin expression and its association with diverse clinical/histological parameters were analyzed. Acute GVHD and DHR displayed varying degrees of elafin expression. No elafin was detectable in csGVHD, whereas the molecule was increased in clGVHD as compared with aGVHD. Elafin-high aGVHD/clGVHD lesions presented with epidermal thickening and were associated with poor prognosis-i.e., decreased overall survival in aGVHD and corticosteroid resistance in clGVHD. Although cutaneous elafin does not seem to discriminate aGVHD from DHR lesions, our study strongly suggests an association between cutaneous elafin expression and poor prognosis for patients with cutaneous GVHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopsy -
- Cohort Studies -
- Elafin - metabolism
- Epidermis - metabolism
- Female -
- Gene Expression Profiling -
- Gene Expression Regulation -
- Graft vs Host Disease - diagnosis
- Graft vs Host Disease - pathology
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans -
- Male -
- Microscopy, Fluorescence -
- Middle Aged -
- Prognosis -
- Real-Time Polymerase Chain Reaction -
- Transforming Growth Factor beta - metabolism
- Treatment Outcome -
- Tumor Necrosis Factor-alpha - metabolism