Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Herzog, S; Pichler, M; Stiegelbauer, V; Stotz, M; Schaberl-Moser, R; Samonigg, H; Asslaber, M; Lax, S; Leitner, G; Renner, W; Lenz, HJ; Berghold, A; Gerger, A.
LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy.
Pharmacogenomics J. 2015; 15(5):391-396
Doi: 10.1038/tpj.2015.2
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- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Asslaber Martin
- Berghold Andrea
- Herzog Sereina Annik
- Leitner Gerhard
- Pichler Martin
- Renner Wilfried
- Samonigg Hellmut
- Schaberl-Moser Renate
- Stiegelbauer Verena
- Stotz Michael
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- Abstract:
- We recently found variants in cancer stem cell genes (CD44, ALCAM and LGR5) significantly associated with increased time to recurrence (TTR) in patients with stage III and high-risk stage II colon cancer treated with 5-fluorouracil (5-FU)-based chemotherapy. In this study, we validated these genetic biomarkers in a large and independent patient cohort (n=599). Patients who received 5-FU-based adjuvant chemotherapy (n=391) carrying at least one C allele in LGR5 rs17109924 had a significantly increased TTR compared with patients carrying the homozygous T/T variant (HR 0.38, 95%CI 0.19-0.79; P=0.006). In patients treated with surgery alone (n=208), no association between LGR rs17109924 and TTR was found (P=0.728). In the multivariate Cox-analysis, LGR5 rs17109924 remained statistically significant (HR 0.38, 95%CI 0.18-0.78; P=0.008) for patients who received adjuvant chemotherapy. We confirmed in a large and independent study cohort that LGR5 rs17109924 is a predictive genetic biomarker for TTR in patients with colon cancer treated with 5-FU-based adjuvant chemotherapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers, Tumor - genetics
- Chemotherapy, Adjuvant -
- Colonic Neoplasms - drug therapy
- Colonic Neoplasms - genetics
- Colonic Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Fluorouracil - administration & dosage
- Humans -
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local -
- Neoplasm Staging -
- Polymorphism, Single Nucleotide -
- Prognosis -
- Receptors, G-Protein-Coupled - genetics