Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Popper, HH.
Lung adenocarcinomas: comparison between mice and men.
Methods Mol Biol. 2015; 1267(2):19-43
Doi: 10.1007/978-1-4939-2297-0_2
PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- A few human tumor types have been modeled in mice using genetic or chemical tools. The final goal of these efforts is to establish models that mimic not only the location and cellular origin of human cancers but also their genetic aberrations and morphologic appearances. The latter has been neglected by most investigators, and comparative histopathology of human versus mouse cancers is not readily available. This issue is exacerbated by the fact that some human malignancies comprise a whole spectrum of cancer subtypes that differ molecularly and morphologically. Lung cancer is a paradigm that appears not only as non-small cell and small-cell lung cancer but comprises a plethora of subtypes with distinct morphologic features. This review discusses species-specific and common morphological features of non-small cell lung cancer in mice and humans. Potential inconsistencies and the need for refined genetic tools are discussed in the context of a comparative analysis between commonly employed RAS-induced mouse tumors and human lung cancers.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - genetics
- Adenocarcinoma - pathology
- Adenocarcinoma of Lung -
- Animals -
- Disease Progression -
- Humans -
- Immunohistochemistry -
- Lung Neoplasms - genetics
- Lung Neoplasms - pathology
- Mice -
- Species Specificity -