Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pinter, M; Hucke, F; Zielonke, N; Trauner, M; Sieghart, W; Peck-Radosavljevic, M.
Epidemiological trends of hepatocellular carcinoma in Austria.
Dig Dis. 2014; 32(6):664-669
Doi: 10.1159/000367983
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Trauner Michael
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- Abstract:
- The heterogeneous epidemiology of hepatocellular carcinoma (HCC) with the highest incidence rates in East Asia, sub-Saharan Africa and Melanesia results from variations in the main risk factors. We investigated epidemiological trends, including incidence and mortality, of patients diagnosed with HCC over a 20-year period in Austria. Data on age-adjusted incidence rates of HCC were obtained from the Austrian National Cancer Registry, which compiles nationwide data on all newly diagnosed cancers. Data on age-adjusted mortality were obtained from the national death registry (Statistics Austria). Of 24,939 patients diagnosed with hepatobiliary tumors between 1990 and 2009, 8,561 subjects had HCC (m/f ratio 75/25%; mean age 69 years). Lymph node and distant metastases were present in 7.5 and 12.2%, respectively. The age-adjusted incidence rate was significantly higher in men than women (m/f ratio 4.5/1) and markedly increased in men (4.68/5.10) but remained stable in women (1.18/1.11). Similarly, the age-adjusted mortality rate was significantly higher in men than women (m/f ratio 4.5/1), increased in men (4.02/4.98) and remained stable in women (0.92/1.0). The median overall survival was 4.5 months for men and 3.2 months for women with 1-/5-year survival rates of 33/11% and 28/10%, respectively. HCC is the most common hepatobiliary neoplasia in Austria and has a very poor prognosis. The age-adjusted incidence and mortality rates were higher in males, increased over time in men and remained stable in women. Extrahepatic metastases were rarely diagnosed and associated with dismal survival.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Distribution -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Carcinoma, Hepatocellular - diagnosis
- Carcinoma, Hepatocellular - epidemiology
- Carcinoma, Hepatocellular - therapy
- Combined Modality Therapy -
- Female -
- Humans -
- Incidence -
- Kaplan-Meier Estimate -
- Liver Neoplasms - diagnosis
- Liver Neoplasms - epidemiology
- Liver Neoplasms - therapy
- Male -
- Middle Aged -
- Prognosis -
- Registries -
- Retrospective Studies -
- Sex Distribution -
- Statistics, Nonparametric -
- Survival Analysis -
- Find related publications in this database (Keywords)
- Hepatocellular carcinoma
- Epidemiology
- Incidence
- Mortality