Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ferlitsch, M; Heinze, G; Salzl, P; Britto-Arias, M; Waldmann, E; Reinhart, K; Bannert, C; Fasching, E; Knoflach, P; Weiss, W; Trauner, M; Ferlitsch, A.
Sex is a stronger predictor of colorectal adenoma and advanced adenoma than fecal occult blood test.
Med Oncol. 2014; 31(9):151-151
Doi: 10.1007/s12032-014-0151-0
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Trauner Michael
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- Abstract:
- Due to high costs and limited availability of screening colonoscopy, some screening programs require a positive fecal occult blood test (FOBT) before screening colonoscopy is remunerated. As male sex is a strong predictor of adenoma and advanced adenoma, we evaluated whether a positive FOBT or male sex is a stronger risk factor for adenoma and advanced adenoma. FOBT and screening colonoscopy results from 18.665 consecutive patients participating in a "national health check program" between 2009 and 2011 were included in this cohort study. Age-corrected adenoma detection rates (ADR), advanced adenoma detection rates (AADR) and carcinoma detection rates were calculated for men and women according to FOBT result separately. ADR and AADR in FOBT-positive men (34.6 and 11.8 %) and FOBT-negative men (29.1 and 7.6 %) were higher than ADR and AADR in FOBT-positive women (20 and 6.9 %) and in FOBT-negative women (17.6 and 4.4 %), (p = 0.0003). Men with negative FOBT were at higher risk of having an adenoma and advanced adenoma than women with positive FOBT (p < 0.0001). Odds ratios of a positive FOBT for ADR and AADR were 1.3 (1.1-1.5) (p = 0.0047) and 1.6 (1.2-2.1) (p < 0.0001), respectively. Odds ratios of male sex to predict ADR and AADR were significantly higher with 1.9 (1.8-2.1) and 1.8 (1.6-2), respectively (p < 0.001). Male sex is a stronger predictor for colorectal adenoma and advanced adenoma than positive FOBT. These results should be taken into account analyzing FOBT-based screening programs.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - diagnosis
- Adenoma - epidemiology
- Adenoma - physiopathology
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Colonic Polyps -
- Colonoscopy -
- Colorectal Neoplasms - diagnosis
- Colorectal Neoplasms - epidemiology
- Colorectal Neoplasms - physiopathology
- Early Detection of Cancer -
- Female -
- Humans -
- Male -
- Mass Screening -
- Middle Aged -
- Occult Blood -
- Odds Ratio -
- Sex Factors -
- Find related publications in this database (Keywords)
- Fecal occult blood test
- Screening colonoscopy
- Adenoma detection rate
- Advanced adenoma detection rate