Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aigner, E; Stadlmayr, A; Huber-Schönauer, U; Zwerina, J; Husar-Memmer, E; Niederseer, D; Trauner, M; Heuberger, A; Hohla, F; Schett, G; Patsch, W; Datz, C.
Gender- and site-specific differences of colorectal neoplasia relate to vitamin D.
Aliment Pharmacol Ther. 2014; 40(11-12):1341-1348
Doi: 10.1111/apt.12981
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- Co-Autor*innen der Med Uni Graz
- Trauner Michael
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- Abstract:
- The effect of vitamin D on colorectal adenomas may vary with regard to gender, localisation and histological type of the lesion. To define the role of vitamin D and gender in a Caucasian cohort of subjects undergoing screening colonoscopy after consideration of established risk factors. One thousand five hundred and thirty-two subjects (813 males, 58.8 ± 9.7 years; 719 females, 59.7 ± 10.7 years) were allocated to tertiles of 25-hydroxyvitamin D3 [25(OH)D3 ] serum concentrations. The number, localisation, size and histology of the detected colonic lesions were recorded. Among men, no association was found between vitamin D and the total number, size and histological stage of adenomas at any site. In female subjects, less women with adenomas were found in the highest vitamin D tertile (N = 42/239; 17.2%) as compared to the low vitamin D group (N = 60/240; 25.0%; P = 0.035). In particular, the number of women with adenomas in the proximal colon was significantly lower in the highest tertile (N = 21/239, 8.8%) compared to the low vitamin D group (N = 41/240; 17.1%; P = 0.007). The rates at other sites were not different. The inverse association of vitamin D serum concentrations with the presence of adenomas in the proximal colon was maintained after adjustment for potential confounders. In 80 women on vitamin D supplementation, the rate of adenomas was lower compared to those not on supplementation (3/80; 3.8%; vs. 90/719; 12.5%; P = 0.016). A potential preventive effect of vitamin D on colorectal adenomas was found in the proximal colon in women. This observation is supported by further decrease of lesions in the proximal colon of women on vitamin D supplementation. © 2014 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - blood
- Adenoma - pathology
- Adenoma - prevention & control
- Adult -
- Aged -
- Aged, 80 and over -
- Cohort Studies -
- Colorectal Neoplasms - blood
- Colorectal Neoplasms - pathology
- Colorectal Neoplasms - prevention & control
- Dietary Supplements -
- Female -
- Humans -
- Male -
- Middle Aged -
- Risk Factors -
- Sex Characteristics -
- Vitamin D - administration & dosage
- Vitamin D - blood
- Vitamin D - pharmacology