Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Medrano, M; Racedo, SM; Rolny, IS; Abraham, AG; Pérez, PF.
Oral administration of kefiran induces changes in the balance of immune cells in a murine model.
J Agric Food Chem. 2011; 59(10):5299-5304
Doi: 10.1021/jf1049968
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Racedo Silvia Maria
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- Abstract:
- The aim of the present study was to evaluate the effect of the oral administration of kefiran on the balance of immune cells in a murine model. Six week old BALB/c mice were treated with kefiran (300 mg/L) for 0, 2 and 7 days. Kefiran treatment increased the number of IgA+ cells in lamina propria after 2 and 7 days. Percentage of B220+/MHCII(high) cells in mesenteric lymph nodes (2 days) and Peyer's patches (7 days) was higher compared to untreated control mice. An increase of macrophages (F4/80+ cells) was observed in lamina propria and peritoneal cavity (2 and 7 days). In contrast, at day 7, macrophage population decreased in Peyer's patches. These results show the ability of kefiran to modify the balance of immune cells in intestinal mucosa. This property could be highly relevant for the comprehension of the probiotic effect attributed to kefir.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Count -
- Immune System - cytology
- Immune System - drug effects
- Immunoglobulin A - analysis
- Intestinal Mucosa - cytology
- Intestinal Mucosa - drug effects
- Intestinal Mucosa - immunology
- Lymph Nodes - cytology
- Lymph Nodes - drug effects
- Macrophages - drug effects
- Mice -
- Mice, Inbred BALB C -
- Models, Animal -
- Peyer's Patches - cytology
- Peyer's Patches - drug effects
- Polysaccharides - administration & dosage
- Find related publications in this database (Keywords)
- kefiran
- GALT
- IgA plus cells
- macrophages
- intestinal mucosa immune response