Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Villena, J; Racedo, S; Agüero, G; Bru, E; Medina, M; Alvarez, S.
Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice.
J Nutr. 2005; 135(6):1462-1469
Doi: 10.1093/jn/135.6.1462
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Racedo Silvia Maria
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- Abstract:
- We studied the effect of Lactobacillus casei CRL 431 used as a supplement in a repletion diet on the resistance to Streptococcus pneumoniae respiratory infection in malnourished mice. Weaned mice were malnourished after they consumed a protein-free diet (PFD) for 21 d. Malnourished mice were fed a balanced conventional diet (BCD) with or without supplemental L. casei for 7, 14, or 21 consecutive days, or BCD for 7 d with L. casei supplementation on d 6 and 7 (7dBCD+2dLc). The malnourished control (MNC) group was fed only the PFD, whereas well-nourished control (WNC) mice consumed the BCD ad libitum. Mice were challenged with S. pneumoniae at the end of each dietary treatment. Lung colonization and bacteremia were significantly greater in MNC than in WNC. Normalization of the immune response occurred in malnourished mice fed the BCD for 21 d. L. casei supplementation reduced the time required for a normal response from 21 to 7 d. Mice administered the 7dBCD+2dLc repletion treatment had a more effective pathogen clearance from blood and significantly lower lung damage than MNC. This treatment improved both the number of leukocytes and neutrophils in blood and bronchoalveolar lavages (BAL) and the bactericidal function of phagocytic cells to levels that did not differ from those of WNC. In the 7dBCD+2dLc mice, antipneumococcal IgA in BAL was higher than in WNC, whereas antipneumococcal IgG in serum and BAL did not differ. This study suggests that the addition of L. casei to the repletion diet has a beneficial effect because it accelerates the recovery of the innate immune response and improves the specific immune mechanisms against an S. pneumoniae respiratory infection in malnourished mice.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Bacterial - analysis
- Antibodies, Bacterial - blood
- Blood - microbiology
- Blood Bactericidal Activity -
- Bronchoalveolar Lavage Fluid - cytology
- Bronchoalveolar Lavage Fluid - immunology
- Colony Count, Microbial -
- Dietary Supplements -
- Immunity -
- Lactobacillus casei - isolation & purification
- Lactobacillus casei - physiology
- Leukocyte Count -
- Lung - microbiology
- Male -
- Mice -
- Phagocytes -
- Pneumococcal Infections - blood
- Pneumococcal Infections - immunology
- Pneumococcal Infections - pathology
- Respiratory Tract Infections - blood
- Respiratory Tract Infections - immunology
- Respiratory Tract Infections - pathology
- Find related publications in this database (Keywords)
- Lactobacillus casei
- malnourished mice
- lung infection
- Streptococcus pneumoniae