Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Carasi, P; Díaz, M; Racedo, SM; De Antoni, G; Urdaci, MC; Serradell, Mde L.
Safety characterization and antimicrobial properties of kefir-isolated Lactobacillus kefiri.
Biomed Res Int. 2014; 2014(Pt 12):208974-208974
Doi: 10.1155/2014/208974
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- Co-Autor*innen der Med Uni Graz
- Racedo Silvia Maria
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- Abstract:
- Lactobacilli are generally regarded as safe; however, certain strains have been associated with cases of infection. Our workgroup has already assessed many functional properties of Lactobacillus kefiri, but parameters regarding safety must be studied before calling them probiotics. In this work, safety aspects and antimicrobial activity of L. kefiri strains were studied. None of the L. kefiri strains tested caused α- or β-hemolysis. All the strains were susceptible to tetracycline, clindamycin, streptomycin, ampicillin, erythromycin, kanamycin, and gentamicin; meanwhile, two strains were resistant to chloramphenicol. On the other hand, all L. kefiri strains were able to inhibit both Gram(+) and Gram(-) pathogens. Regarding the in vitro results, L. kefiri CIDCA 8348 was selected to perform in vivo studies. Mice treated daily with an oral dose of 10(8) CFU during 21 days showed no signs of pain, lethargy, dehydration, or diarrhea, and the histological studies were consistent with those findings. Moreover, no differences in proinflammatory cytokines secretion were observed between treated and control mice. No translocation of microorganisms to blood, spleen, or liver was observed. Regarding these findings, L. kefiri CIDCA 8348 is a microorganism isolated from a dairy product with a great potential as probiotic for human or animal use.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cultured Milk Products - adverse effects
- Cultured Milk Products - microbiology
- Gram-Negative Bacteria - drug effects
- Gram-Positive Bacteria - drug effects
- Humans -
- Lactobacillus - metabolism
- Lactobacillus - pathogenicity
- Mice -
- Microbial Sensitivity Tests -
- Probiotics - administration & dosage
- Probiotics - adverse effects