Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Herzberg, PY; Lee, SJ; Heussner, P; Mumm, FH; Hilgendorf, I; von Harsdorf, S; Hemmati, P; Rieger, K; Greinix, HT; Freund, M; Holler, E; Wolff, D.
Personality influences quality-of-life assessments in adult patients after allogeneic hematopoietic SCT: results from a joint evaluation of the prospective German Multicenter Validation Trial and the Fred Hutchinson Cancer Research Center.
Bone Marrow Transplant. 2013; 48(1):129-134
Doi: 10.1038/bmt.2012.83
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The influence of personality on health related quality of life (QoL) and physical functioning in the setting of allogeneic hematopoietic SCT (alloHSCT) is unknown. We conducted a joint evaluation within two independent cohorts of alloHSCT recipients to investigate the impact of personality on reported QoL and physical functioning. Two-hundred-eight patients (median age 44 years, range 18-72) of cohort 1 and 93 patients (median age 55 years, range 19-79) of cohort 2 after alloHSCT were evaluated. Personality was assessed using the 24-adjective measure (AM), which measures the Big-Five personality domains and the Life Orientation Test-Revised (LOT-R), measuring optimism and pessimism. QoL was measured using the Functional Assessment of Cancer Therapy with bone marrow transplantation subscale (FACT-BMT), Short Form 36 (SF-36), the human activity profile (HAP), as well as the NIH criteria-based cGVHD activity assessment form and the Lee cGVHD symptom scale. Neuroticism was significantly associated with worse function measured by the HAP and FACT-BMT. Optimism significantly improved QoL captured by the FACT-BMT. Pessimism significantly impaired physical function captured by the HAP and SF-36. Extraversion was significantly associated with reduced depression and lower severity of cGVHD symptoms reported by the patient and the physician. The results suggest that personality traits and pre-treatment QoL assessments should be measured in clinical trials to facilitate the interpretation of QoL data.
- Find related publications in this database (using NLM MeSH Indexing)
- Activities of Daily Living -
- Adolescent -
- Adult -
- Aged -
- Anxiety Disorders - complications Anxiety Disorders - psychology
- Anxiety Disorders -
- Cohort Studies -
- Follow-Up Studies -
- Follow-Up Studies -
- Graft vs Host Disease - complications Graft vs Host Disease - physiopathology Graft vs Host Disease - psychology
- Hematologic Neoplasms - complications Hematologic Neoplasms - psychology Hematologic Neoplasms - therapy
- Hematopoietic Stem Cell Transplantation - psychology
- Humans -
- Longitudinal Studies -
- Middle Aged -
- Personality -
- Personality Disorders - complications Personality Disorders - psychology
- Prospective Studies -
- Quality of Life -
- Severity of Illness Index -
- Transplantation, Homologous -
- Transplantation, Homologous -
- Young Adult -
- Find related publications in this database (Keywords)
- allogeneic hematopoietic SCT
- personality
- GVHD
- quality of life
- physical functioning