Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Worel, N; Böhm, A; Rabitsch, W; Leitner, G; Mitterbauer, M; Kalhs, P; Mayr, WR; Schwartz, D; Greinix, HT.
Frequency and prognostic value of D alloantibodies after D-mismatched allogeneic hematopoietic stem cell transplantation after reduced-intensity conditioning.
Transfusion. 2012; 52(6):1348-1353 Doi: 10.1111/j.1537-2995.2011.03457.x
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Greinix Hildegard
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Due to the fact that the ABO and D system is inherited independently from the HLA system, approximately 40% of allogeneic hematopoietic stem cell transplants (HSCT) are performed across the blood group barrier. Reports on the development of de novo anti-D in patients undergoing reduced-intensity conditioning (RIC) followed by D-mismatched allogeneic HSCT are rare. The objective of this study was to evaluate the frequency of anti-D alloimmunization after D-mismatched HSCT following RIC and its prognostic impact on transplant outcome. Forty patients with hematologic diseases who underwent D-mismatched HSCT were retrospectively analyzed: 19 D- patients with a D+ donor and 21 D+ patients with a D- donor. Routine serologic testing for blood group typing and antibody screening was performed by a column agglutination method every time when transfusion of red blood cell units was requested and in the posttransplantation course to demonstrate establishment of donor ABO type and to detect alloimmunization. After a median serologic follow-up of 21 (range, 0 to 73) months after HSCT, anti-D was identified in 2 of 21 (10%) D+ patients receiving a D- transplant, 23 and 34 months after HSCT. None of the 19 D- patients with a D+ donor developed an anti-D. We observed an infrequent de novo anti-D formation that is more likely in D+ recipients of D- grafts. However, the development of anti-D does not normally impair the transplant outcome and is not of clinical relevance in the posttransplant course. © 2011 American Association of Blood Banks.
Find related publications in this database (using NLM MeSH Indexing): ABO Blood-Group System - blood ABO Blood-Group System - immunology; Adult -; Blood Group Incompatibility - blood Blood Group Incompatibility - diagnosis Blood Group Incompatibility - epidemiology Blood Group Incompatibility - immunology; Blood Grouping and Crossmatching -; Female -; Graft vs Host Disease - blood Graft vs Host Disease - diagnosis Graft vs Host Disease - etiology Graft vs Host Disease - immunology; Hematopoietic Stem Cell Transplantation - methods; Humans -; Isoantibodies - analysis Isoantibodies - blood; Male -; Middle Aged -; Predictive Value of Tests -; Retrospective Studies -; Seroepidemiologic Studies -; Transplantation Conditioning - adverse effects Transplantation Conditioning - methods; Transplantation, Homologous -