Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kuzmina, Z; Greinix, HT; Weigl, R; Körmöczi, U; Rottal, A; Frantal, S; Eder, S; Pickl, WF.
Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia.
Blood. 2011; 117(7): 2265-2274.
Doi: 10.1182/blood-2010-07-295766
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- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Manifestations of chronic graft-versus-host disease (cGVHD) can resemble those seen in immunodeficiency states and autoimmune disorders. Reports by us and others suggest an involvement of B cells in the pathogenesis of cGVHD. We investigated B-lymphocyte subpopulations in cGVHD cohorts defined by serum immunoglobulin G (IgG) levels to characterize novel biomarkers for impairment of humoral immunity after allogeneic hematopoietic stem cell transplantation. Seventy-six patients were enrolled a median of 46 months after hematopoietic stem cell transplantation. The hypogammaglobulinemia group had significantly diminished CD19(+) B cells (165 vs 454 vs 417 × 10⁶L) with elevated CD19(+)CD21(low) immature (16.5%, 7.7%, and 9.1%) and CD19(+)CD21(int-high)CD38(high)IgM(high) transitional (10.5% vs 4.2% vs 6.3%) B-cell proportions compared with the normogammaglobulinemia and hypergammaglobulinemia groups. CD19(+)CD10(-)CD27(-)CD21(high) naive B cells were highly elevated in all patients with cGVHD. CD19(+)CD27(+)IgD(+) non-class-switched (4 vs 12 vs 11 × 10⁶/L) and class-switched (7 vs 35 vs 42 × 10⁶/L) memory B cells were significantly lower in the hypogammaglobulinemia group compared with the others. Besides significantly higher B-cell activation factor/B-cell ratios, significantly more cGVHD patients with hypergammaglobulinemia had autoantibodies compared with the hypogammaglobulinemia subgroup (68% vs 24%, P = .024). In conclusion, B-cell subpopulations can serve as novel cellular biomarkers for immunodeficiency and autoimmunity indicating different pathogenetic mechanisms of cGVHD and encouraging future prospective longitudinal studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Autoantibodies - blood
- B-Cell Activating Factor - immunology
- B-Lymphocyte Subsets - immunology
- Chronic Disease -
- Cohort Studies -
- Common Variable Immunodeficiency - etiology Common Variable Immunodeficiency - immunology
- Dysgammaglobulinemia - etiology Dysgammaglobulinemia - immunology
- Female -
- Graft vs Host Disease - etiology Graft vs Host Disease - immunology
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans -
- Hypergammaglobulinemia - etiology Hypergammaglobulinemia - immunology
- Immunity, Humoral -
- Immunoglobulin G - blood
- Male -
- Middle Aged -
- Transplantation, Homologous -
- Young Adult -