Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Knobler, R; Barr, ML; Couriel, DR; Ferrara, JL; French, LE; Jaksch, P; Reinisch, W; Rook, AH; Schwarz, T; Greinix, H.
Extracorporeal photopheresis: past, present, and future.
J Am Acad Dermatol. 2009; 61(4): 652-665.
Doi: 10.1016/j.jaad.2009.02.039
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Extracorporeal photopheresis (ECP) is a leukapheresis-based therapy that uses 8-methoxypsoralen and ultraviolet A irradiation. Used alone or in combination with biological agents, ECP is an established and effective therapy for advanced cutaneous T-cell lymphoma. ECP has also shown promising efficacy in a number of other severe and difficult-to-treat conditions, including systemic sclerosis, graft-versus-host disease, prevention and treatment of rejection in solid organ transplantation, and Crohn disease. Furthermore, the use of ECP in some of these conditions may allow a significant reduction in the use of systemic steroids and other immunosuppressants, reducing long-term morbidity and mortality. The accumulated experience shows ECP to be well tolerated, with no clinically significant side effects. Progress is also being made in the search for understanding of the mechanisms of action of ECP, which will ultimately facilitate improvements in the use of this therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Autoimmune Diseases - immunology Autoimmune Diseases - therapy
- Humans -
- Photopheresis - methods Photopheresis - trends
- Skin Diseases - immunology Skin Diseases - therapy
- Skin Neoplasms - immunology Skin Neoplasms - therapy
- Find related publications in this database (Keywords)
- extracorporeal photopheresis
- cutaneous T-cell lymphoma
- mycosis fungoides
- Sezary syndrome
- systemic sclerosis
- graft-versus-host disease
- solid organ transplant
- cardiac transplant
- lung transplant
- bronchiolitis obliterans
- bronchiolitis obliterans syndrome
- liver transplant
- renal transplant
- Crohn disease
- atopic dermatitis
- lichen planus
- contact hypersensitivity mouse model
- T-cell clonality
- bone marrow transplant