Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holler, E; Rogler, G; Brenmoehl, J; Hahn, J; Herfarth, H; Greinix, H; Dickinson, AM; Socié, G; Wolff, D; Fischer, G; Jackson, G; Rocha, V; Steiner, B; Eissner, G; Marienhagen, J; Schoelmerich, J; Andreesen, R.
Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.
Blood. 2006; 107(10): 4189-4193.
Doi: 10.1182/blood-2005-09-3741
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- To assess the role of NOD2/CARD15 variants on the long-term outcome of allogeneic stem cell transplantation in a genetically homogeneous group, we extended our previous study (cohort I, n = 78) and typed DNA for NOD2/CARD15 single nucleotide polymorphisms (SNPs) from an additional 225 recipients and their HLA-identical sibling donors (cohort II) treated at four other European centers. Results of genotyping were compared with clinical outcome. The strong association of NOD2/CARD15 variants with transplantation-related mortality (TRM) was confirmed in univariate and multivariate analysis; TRM increased from 20% in cohort I/22% in cohort II in recipient/donor pairs without any NOD2/CARD15 variants to 47% in cohort I/32% in cohort II in the presence of one variant in either donor or recipient and further to 57% in cohort I/74% in cohort II in the presence of 2 or more variants (P < .002 in both cohorts). NOD2/CARD15 SNPs were not associated with relapse rate but had a strong impact on overall survival. In an analysis of center effects, the type of gastrointestinal decontamination was the only factor interfering with the prognostic significance of NOD2/CARD15 SNPs. Our data further support an interaction between gastrointestinal defense mechanisms, activation of the innate immune system, and specific transplant-related complications.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Child -
- Child, Preschool -
- Cohort Studies -
- Female -
- Genetic Variation -
- HLA Antigens - genetics
- Hematologic Diseases - genetics Hematologic Diseases - therapy
- Humans -
- Intracellular Signaling Peptides and Proteins - genetics
- Leukemia - genetics Leukemia - therapy
- Male -
- Middle Aged -
- Nod2 Signaling Adaptor Protein -
- Polymorphism, Single Nucleotide -
- Siblings -
- Stem Cell Transplantation -
- Transplantation, Homologous -
- Treatment Outcome -