Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holler, E; Rogler, G; Brenmoehl, J; Hahn, J; Greinix, H; Dickinson, AM; Socie, G; Wolff, D; Finke, J; Fischer, G; Jackson, G; Rocha, V; Hilgendorf, I; Eissner, G; Marienhagen, J; Andreesen, R.
The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation.
Int J Immunogenet. 2008; 35(4-5): 381-384.
Doi: 10.1111/j.1744-313X.2008.00795.x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Previous studies from our group indicated a role of SNPs within the innate immunity receptor NOD2/CARD15 as a risk factor for GvHD and treatment-related mortality allogeneic stem cell transplantation from HLA-identical siblings. We now extended these studies to assess the role of NOD2/CARD15 SNPs in 342 unrelated donor transplants. Overall, presence of any SNPs in patients or donor resulted in an increased risk of severe GvHD (25% in wildtype versus 38% in recipients and donors with variants, P= 0.01), which did not translate in increased mortality. When the analysis was broken down to individual SNPs, the presence of a SNP13 in the donor turned out to be the only highly significant risk factor (GvHD III/IV 22% wt, 42% SNP13 donor, P < 0.004; TRM 33% wt versus 59% SNP13 donor, P= 0.01; overall survival 49% wt versus 26% SNP13 donor, P= 0.007). This association was confirmed in multivariate analysis. Analysis of clinical risk factors suggested that this effect was most prominent in patients receiving any form of T cell depletion. Thus our observation indicates that the presence of a defect in innate immunity signalling in donor monocytes and possibly antigen presenting cells is most prominent in patients having additional T cell deficiency.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Clinical Protocols -
- Female -
- Gene Frequency -
- Genetic Variation -
- Graft vs Host Disease - genetics Graft vs Host Disease - immunology
- Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality
- Humans -
- Immunity, Innate -
- Lymphocyte Depletion -
- Male -
- Middle Aged -
- Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - immunology
- Polymorphism, Single Nucleotide - genetics
- Tissue Donors -
- Young Adult -