Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weltermann, A; Fonatsch, C; Haas, OA; Greinix, HT; Kahls, P; Mitterbauer, G; Jäger, U; Kainz, B; Geissler, K; Valent, P; Sperr, WR; Knöbl, P; Schwarzinger, I; Gleiss, A; Lechner, K.
Impact of cytogenetics on the prognosis of adults with de novo AML in first relapse.
Leukemia. 2004; 18(2): 293-302.
Doi: 10.1038/sj.leu.2403243
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Karyotype is an important prognostic factor in patients with newly diagnosed acute myeloblastic leukaemia (AML). The prognostic value of cytogenetics on the outcome of patients with AML in relapse has not yet been well defined. We analysed the clinical outcome of 152 patients with de novo, chemotherapy-treated AML in first relapse according to the cytogenetic classification of the United Kingdom Medical Research Council. The rate of second complete remission (CR) (88, 64 and 36%) and the probability of survival at 3 years (43, 18 and 0%) were significantly different between the favourable, intermediate and adverse cytogenetic risk groups, respectively. Compared to the favourable group, the relative risk (RR) of death (multivariate analyses) was 2.6 (confidence interval (CI): 1.5-4.4, P<0.001) for the intermediate and 3.7 (CI: 1.7-7.9, P=0.001) for the adverse group. The prognostic value of the duration of first CR was confirmed (RR of death: 2.0 (CI: 1.0-4.0) for each additional year in first CR), whereas the FLT3 mutation obtained at diagnosis did not markedly influence the outcome of patients with AML in relapse. In conclusion, our results indicate that both karyotype and the duration of first CR are independent prognostic factors for patients with de novo AML in first relapse.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Classification -
- Cytogenetic Analysis -
- Female -
- Follow-Up Studies -
- Humans -
- Karyotyping -
- Leukemia, Myeloid - diagnosis Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality
- Male -
- Middle Aged -
- Prognosis -
- Proto-Oncogene Proteins - genetics
- Receptor Protein-Tyrosine Kinases - genetics
- Recurrence -
- Remission Induction -
- Survival Analysis -
- Treatment Outcome -
- fms-Like Tyrosine Kinase 3 -
- Find related publications in this database (Keywords)
- karyotype
- cytogenetics
- acute myeloid leukaemia
- relapse
- FLT3