Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Greinix, HT; Knobler, RM; Worel, N; Schneider, B; Schneeberger, A; Hoecker, P; Mitterbauer, M; Rabitsch, W; Schulenburg, A; Kalhs, P.
The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease.
Haematologica. 2006; 91(3): 405-408.
[OPEN ACCESS]
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Acute graft-versus-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell transplantation. We performed a phase II study on patients with acute steroid-refractory GVHD grades II to IV given extracorporeal photochemotherapy (ECP) weekly and analyzed response and long-term survival. Complete resolution of GVHD was achieved in 82% of patients with cutaneous involvement, 61% with liver involvement, and 61% with gut involvement. The probability of survival was 59% among patients who responded completely to ECP compared to 11% in patients not responding completely. We conclude that intensified ECP is highly effective in acute GVHD and that sustained responses are associated with over 50% long-term survival.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Female -
- Graft vs Host Disease - mortality Graft vs Host Disease - radiotherapy
- Hematopoietic Stem Cell Transplantation - mortality
- Humans -
- Male -
- Middle Aged -
- Photopheresis - methods
- Pilot Projects -
- Survival Rate -
- Time -
- Find related publications in this database (Keywords)
- acute graft-versus-host disease
- extracorporeal photochemotherapy