Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schulenburg, A; Turetschek, K; Wrba, F; Vogelsang, H; Greinix, HT; Keil, F; Mitterbauer, M; Kalhs, P.
Early and late gastrointestinal complications after myeloablative and nonmyeloablative allogeneic stem cell transplantation.
Ann Hematol. 2004; 83(2): 101-106.
Doi: 10.1007/s00277-003-0756-4
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Upper and lower gastrointestinal symptoms are major and serious complications after stem cell transplantation. Their main causes are gastrointestinal graft-versus-host disease (GVHD), infections, toxicity, or preexisting gastrointestinal diseases. The clinical presentation of each disease is nonspecific. The diagnostic procedure for this study included physical exam, stool cultures, endoscopy with biopsies, and abdominal computed tomography (CT). The study was designed prospectively with consecutive patients and performed at our institution in a clinical stem cell transplantation setting. Between January 1996 and September 2001, we analyzed 42 consecutive patients who had been admitted at our institution for gastrointestinal complaints after allogeneic stem cell transplantation for hematologic diseases. Diagnostic procedures revealed in decreasing order: GVHD (62%), gastritis/esophagitis (19%), cytomegalovirus (CMV) enteritis (11%), bacterial enteritis (6%), and toxic mucosal damage (2%). CT showed unspecific findings. Gastrointestinal GVHD and infectious colitis accounted for the majority of gastrointestinal complications after allogeneic stem cell transplantation in our patient population. The diagnosis was mainly based on endoscopically obtained biopsies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Bacterial Infections - etiology
- Bone Marrow Transplantation - adverse effects
- Cytomegalovirus Infections - etiology
- Female -
- Gastric Mucosa - microbiology Gastric Mucosa - pathology
- Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - etiology Gastrointestinal Diseases - pathology
- Graft vs Host Disease - etiology Graft vs Host Disease - pathology
- Humans -
- Intestinal Mucosa - microbiology Intestinal Mucosa - pathology
- Male -
- Middle Aged -
- Myeloablative Agonists - adverse effects Myeloablative Agonists - therapeutic use
- Prospective Studies -
- Stem Cell Transplantation - adverse effects Stem Cell Transplantation - methods
- Transplantation Conditioning - adverse effects
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- gastrointestinal complications
- bone marrow transplantation