Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kokalj, A; Greinix, HT; Ciovica, M; Kittler, H; Kalhs, P; Knobler, RM; Volc-Platzer, B.
Effects of extracorporeal photoimmunotherapy on soluble IL-2Ralpha, TNF-RI, and CD8 in patients with steroid-resistant acute graft-versus-host disease.
Clin Immunol. 2002; 104(3):248-255
Doi: 10.1006/clim.2001.5240
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Extracorporeal photoimmunotherapy (ECP) has been successfully used as adjunct treatment for steroid-resistant graft-versus-host disease (GvHD) after allogeneic stem cell transplantation. We serially investigated serum levels of soluble interleukin-2 receptor-alpha (sIL-2Ralpha), soluble tumor necrosis factor receptor I (sTNF-RI), and soluble CD8 (sCD8) in 19 patients with steroid-resistant acute GvHD before and after each ECP treatment. Highest levels of sIL-2Ralpha and sTNF-RI correlated with severe acute GvHD and infections. Despite an immediate sIL-2Ralpha and sTNF-RI decrease after each treatment cycle, a mean surge of sTNF-RI>sIL-2Ralpha during the first three ECP cycles was observed in infections. A delayed surge, i.e., after the third ECP cycle, of sIL-2Ralpha and elevated post-ECP sCD8 levels was observed in patients developing chronic GvHD. While levels of sIL-2Ralpha and sTNF-RI correlate with the severity of acute GvHD and infections during the early ECP treatment period, the recurring increase of post-ECP sCD8 possibly may serve as parameter for developing chronic GvHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adult -
- Antigens, CD - blood
- Antigens, CD8 - blood
- Bone Marrow Transplantation - adverse effects
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Graft vs Host Disease - immunology Graft vs Host Disease - therapy
- Humans -
- Immunotherapy -
- Interleukin-2 Receptor alpha Subunit -
- Male -
- Middle Aged -
- Phototherapy -
- Receptors, Interleukin - blood
- Receptors, Tumor Necrosis Factor - blood
- Receptors, Tumor Necrosis Factor, Type I -
- Stem Cell Transplantation - adverse effects
- Find related publications in this database (Keywords)
- immune-activation markers
- acute GvHD
- extracorporeal photoimmunotherapy