Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mitterbauer, M; Kalhs, P; Keil, F; Prinz, E; Moser, K; Mannhalter, C; Mitterbauer, G; Brugger, S; Gisslinger, H; Lechner, K; Greinix, HT.
Continuous complete clinical and molecular remission in two patients with refractory lymphoid malignancies after autografting followed by allogeneic stem cell transplantation with reduced intensity conditioning.
Br J Haematol. 2002; 118(1):132-135
Doi: 10.1046/j.1365-2141.2002.03562.x
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- We present a 60-year-old patient with primary refractory non-Hodgkin's lymphoma and a 58-year-old patient with multiple myeloma with relapse after first autologous stem cell transplantation (ASCT), who underwent ASCT followed by allogeneic stem cell transplantation (alloSCT) with reduced intensity conditioning consisting of fludarabine and a single dose of total body irradiation. For graft-versus-host disease prophylaxis cyclosporine and mycophenolate mofetyl were given. Complete donor chimaerism was observed on d 28 after SCT. Both patients achieved sustained complete haematological and molecular remission of the immunoglobulin kappa light chain (Igkappa) rearrangement and are alive and well 17 and 16 months after SCT respectively.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - therapeutic use
- Female -
- Hematopoietic Stem Cell Transplantation - methods
- Humans -
- Immunoglobulin G -
- Lymphoma, B-Cell - surgery
- Middle Aged -
- Multiple Myeloma - immunology Multiple Myeloma - surgery
- Remission Induction -
- Reoperation -
- Transplantation Conditioning -
- Transplantation, Autologous -
- Transplantation, Homologous -
- Vidarabine - analogs & derivatives Vidarabine - therapeutic use
- Whole-Body Irradiation -
- Find related publications in this database (Keywords)
- lymphoid malignancies
- autologous stem cell transplantation
- allogeneic stem cell transplantation
- reduced intensity conditioning
- immunoglobulin kappa light chain (Ig kappa) rearrangement