Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hildebrandt, GC; Granell, M; Urbano-Ispizua, A; Wolff, D; Hertenstein, B; Greinix, HT; Brenmoehl, J; Schulz, C; Dickinson, AM; Hahn, J; Rogler, G; Andreesen, R; Holler, E.
Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.
Biol Blood Marrow Transplant. 2008; 14(1): 67-74.
Doi: 10.1016/j.bbmt.2007.09.009
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Bronchiolitis obliterans (BO) is a serious complication after allogeneic stem cell transplantation. We hypothesized that single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene (=NOD2/CARD15 variants) contribute to changes in host defense and subsequent alloreaction, leading to BO. We analyzed 427 donor-recipient pairs for the association of NOD2/CARD15 variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) with BO occurrence. Overall, 11 patients (2.6%) developed BO. The cumulative incidence of BO rose from 1.3% in donor-recipient pairs without mutation to 18.7% in pairs with donor or recipient NOD2/CARD15 variants (P < .001). Recipient NOD2/CARD15 variants alone led to BO in 22.3% (P < .001), whereas donor variants alone associated with BO in 13.2% (P = .04). Multivariate analysis proved recipient but not donor NOD2/CARD15 variants to be a novel independent risk factor for BO development, and NOD2/CARD15 typing may help identify patients at increased risk for BO.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Bronchiolitis Obliterans - genetics Bronchiolitis Obliterans - immunology
- Female -
- Genetic Predisposition to Disease - genetics
- Graft vs Host Disease - genetics
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans -
- Male -
- Middle Aged -
- Nod2 Signaling Adaptor Protein - genetics
- Polymorphism, Single Nucleotide - genetics Polymorphism, Single Nucleotide - immunology
- Risk Factors -
- Transplantation, Homologous - adverse effects
- Find related publications in this database (Keywords)
- bronchiolitis obliterans
- chronic GVHD
- NOD2
- stem cell transplantation