Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rabitsch, W; Knöbl, P; Prinz, E; Keil, F; Greinix, H; Kalhs, P; Worel, N; Jansen, M; Hörl, WH; Derfler, K.
Prolonged red cell aplasia after major ABO-incompatible allogeneic hematopoietic stem cell transplantation: removal of persisting isohemagglutinins with Ig-Therasorb immunoadsorption.
Bone Marrow Transplant. 2003; 32(10):1015-1019
Doi: 10.1038/sj.bmt.1704264
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Delayed donor red cell engraftment and prolonged red cell aplasia (PRCA) are well-recognized complications of major ABO-incompatible myeloablative and non-myeloablative hematopoietic stem cell transplantation (HSCT). There is an intense debate about the impact on outcome, severity of hemolysis, association with graft-versus-host disease and survival after blood group-incompatible stem cell transplantation. Therefore, therapeutic strategies should be considered to avoid these possible complications. We present five patients, who received allogeneic HSCT from human leukocyte antigen-identical donors for hematological malignancies, which were treated with Ig-Therasorb immunoadsorption (five treatments/week) to remove persisting incompatible isohemagglutinins. After a median of 17 treatments (range 9-25), all the patients became transfusion independent with the presentation of donor's blood group. No side effects occurred during treatment. Ig-Therasorb immunoadsorption seems to be a promising therapeutic method for rapid, efficient and safe elimination for persisting isohemagglutinins for patients with PRCA after allogeneic hematological stem cell transplantation.
- Find related publications in this database (using NLM MeSH Indexing)
- ABO Blood-Group System - immunology
- Adult -
- Blood Group Incompatibility -
- Female -
- Hemagglutinins - isolation & purification
- Hematologic Neoplasms - complications Hematologic Neoplasms - therapy
- Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods
- Histocompatibility -
- Humans -
- Immunosorbent Techniques -
- Male -
- Middle Aged -
- Red-Cell Aplasia, Pure - etiology Red-Cell Aplasia, Pure - therapy
- Transplantation, Homologous -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- red cell aplasia
- stem cell transplantation
- immunoadsorption