Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schulenburg, A; Fischer, M; Kalhs, P; Mitterbauer, M; Rabitsch, W; Greinix, HT; Leitner, G.
Immune recovery after conventional and non-myeloablative allogeneic stem cell transplantation.
Leuk Lymphoma. 2005; 46(12): 1755-1760.
Doi: 10.1080/10428190500264496
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- Co-authors Med Uni Graz
- Greinix Hildegard
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- Abstract:
- The immune recovery of 66 patients undergoing allogeneic stem cell transplantation with either conventional or non-myeloablative conditioning regimen was studied. Infections post-transplant were enumerated and quantitative immunoglobuilins (IgG, IgA, IgM) and lymphocyte sub-sets 3, 6 and 12 months post-transplant were measured. A significant difference was found in the immunologic recovery of non-myeloablative and conventional ASCT in the patient population. The T-helper cell reconstitution was significantly faster after NMA than conventional transplantation and the recovery of B cells was faster after conventional transplantation. Regarding immunoglobulin levels, a faster recovery of IgM levels after NMA-ASCT and a delayed recovery of IgA levels was observed in both groups. These were accompanied by a significant difference in the frequency and severity of infectious episodes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Cells - pathology
- Female -
- Follow-Up Studies -
- Graft vs Host Disease - epidemiology
- Humans -
- Leukemia - therapy
- Leukocyte Count -
- Lymphocyte Subsets - immunology
- Lymphoma - therapy
- Male -
- Middle Aged -
- Stem Cell Transplantation - methods
- T-Lymphocytes, Helper-Inducer - immunology
- Transplantation Conditioning - methods
- Transplantation, Homologous - immunology
- Find related publications in this database (Keywords)
- immune reconstitution
- recovery
- non-myeloablative
- stem cell transplant
- allogeneic transplantation