Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Worel, N; Greinix, HT; Leitner, G; Mitterbauer, M; Rabitsch, W; Rosenmayr, A; Höcker, P; Kalhs, P.
ABO-incompatible allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning: close association with transplant-associated microangiopathy.
Transfus Apher Sci. 2007; 36(3): 297-304. Doi: 10.1016/j.transci.2007.03.004
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Co-Autor*innen der Med Uni Graz: Greinix Hildegard
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Abstract:: Transplant-associated microangiopathy (TAM) is a severe complication following allogeneic hematopoietic stem cell transplantation (HSCT) even after reduced-intensity conditioning (RIC). Data on 112 patients following RIC were analyzed with respect to TAM according to the ASBMT and risk factors, response to well-defined therapy and outcome were determined. TAM occurred in 11 of 112 patients. Univariate analysis determined acute graft-versus-host disease and ABO-incompatibility as risk factors for TAM. Treatment consisted of withdrawal of calcineurin inhibitors and plasma exchange (PE). Response to PE was 64%. PE seems to be an effective therapeutic option that should be assessed in larger patient cohorts.
Find related publications in this database (using NLM MeSH Indexing): ABO Blood-Group System - immunology; Adolescent -; Adult -; Aged -; Blood Group Incompatibility - complications; Female -; Graft vs Host Disease -; Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods; Humans -; Male -; Microcirculation -; Microvessels - pathology; Middle Aged -; Peripheral Vascular Diseases - etiology Peripheral Vascular Diseases - therapy; Plasma Exchange -; Risk Factors -; Transplantation Conditioning - methods; Transplantation, Homologous -; Treatment Outcome -; Young Adult -