Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Worel, N; Kalhs, P; Keil, F; Prinz, E; Moser, K; Schulenburg, A; Mitterbauer, M; Mannhalter, C; Mayr, WR; Schwarzinger, I; Höcker, P; Lechner, K; Greinix, HT.
ABO mismatch increases transplant-related morbidity and mortality in patients given nonmyeloablative allogeneic HPC transplantation.
Transfusion. 2003; 43(8):1153-1161
Doi: 10.1046/j.1537-2995.2003.00465.x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- ABO mismatch has not been thought to affect the outcome of patients undergoing myeloablative conditioning and allogeneic HPC transplantation. Data on transplant-related complications after ABO-mismatched transplantation after nonmyeloablative conditioning are limited. Therefore, 40 patients were analyzed after nonmyeloablative conditioning with regard to ABO compatibility. Eleven received a minor and bidirectional and 8 a major ABO-mismatched graft. Four patients had evidence of hemolysis during engraftment, being lethal in one, and three developed pure RBC aplasia. Six patients in the ABO-mismatched group developed thrombotic microangiopathy, and three of them died. ABO-identical and ABO-mismatched patients had a similar incidence of GVHD. Viral infections occurred in both groups in equal shares. Patients with an ABO-mismatch had to be rehospitalized until Day 100 for a median of 19 days versus 0 days in the identical group (p < 0.05). Overall survival was 60 and 57 percent in the ABO-identical and ABO-mismatch groups, respectively. The probability of transplant-related mortality was 0 versus 28 percent in the identical group compared to patients with an ABO mismatch (p < 0.05). The probability of relapse or progression was 76 versus 25 percent in the ABO-identical group compared to the ABO-mismatched group, respectively. Significantly more patients with ABO mismatch showed transplant-associated complications and died as a result of transplant-related causes.
- Find related publications in this database (using NLM MeSH Indexing)
- ABO Blood-Group System -
- Adult -
- Aged -
- Blood Group Incompatibility - complications
- Central Nervous System Diseases - etiology
- Disease Progression -
- Female -
- Graft vs Host Disease - etiology
- Hematologic Diseases - etiology
- Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality
- Hospitalization -
- Humans -
- Immune System Diseases - etiology
- Infection - etiology
- Male -
- Middle Aged -
- Recurrence -
- Survival Analysis -
- Transplantation, Homologous -