Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Prinz, E; Keil, F; Kalhs, P; Mitterbauer, M; Rabitsch, W; Rosenmayr, A; Moser, K; Schulenburg, A; Lechner, K; Greinix, HT.
Successful immunotherapy in early relapse of acute myeloid leukemia after nonmyeloablative allogeneic stem cell transplantation.
Ann Hematol. 2003; 82(5):295-298
Doi: 10.1007/s00277-003-0621-5
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- We report on a 35-year-old woman who underwent allogeneic stem cell transplantation (SCT) in second complete remission (CR) of acute myeloid leukemia (AML) after reduced-intensity conditioning with fludarabine and 2 Gy of total body irradiation. For graft-versus-host disease (GVHD) prophylaxis, cyclosporin A (CsA) and mycophenolate mofetil (MMF) were given. On day 27 after SCT complete hematological remission and donor chimerism was documented. However, in CD34(+) bone marrow cells 28% of recipient hematopoiesis persisted. On day +59 leukemic relapse occurred. After discontinuation of CsA and onset of GVHD, complete donor chimerism and hematological CR were achieved which has been maintained for 14 months.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adult -
- Combined Modality Therapy -
- Female -
- Graft vs Host Disease - prevention & control
- Hematopoietic Stem Cell Transplantation - methods
- Humans -
- Immunosuppressive Agents - therapeutic use
- Immunotherapy -
- Leukemia, Myeloid - therapy
- Recurrence -
- Remission Induction -
- Transplantation Conditioning - methods
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- AML
- nonmyeloablative allogeneic stem cell transplantation
- immunotherapy