Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leitner, GC; Baumgartner, K; Kalhs, P; Biener, D; Greinix, HT; Hoecker, P; Worel, N.
Regeneration, health status and quality of life after rhG-CSF-stimulated stem cell collection in healthy donors: a cross-sectional study.
Bone Marrow Transplant. 2009; 43(5): 357-363.
Doi: 10.1038/bmt.2008.335
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Mobilized allogeneic PBPC are increasingly used instead of BM for allogeneic stem cell grafting. Although the short-term safety profile of recombinant human (rh)G-CSF seems acceptable, only minimal data on long-term safety are available. We therefore reviewed data on 171 sibling donors (M/F: 98/73) with respect to side effects of rhG-CSF and PBPC collection and impact on quality of life (QoL) and health status. In a cross-sectional study, we investigated the actual QoL and health status of the donors as well as the need for medical treatment since PBPC donation by a questionnaire that was sent to 151 donors. Ninety-five (64%) of the addressed donors responded to the questionnaire, but only 69 (46%) of them reported on their actual health status and QoL, which was good to very good in the majority of them. Two donors developed malignancies in the post-donation course. In general, PBPC collection after rhG-CSF mobilization was well tolerated by the responding donors. Although the reported events in medical history after PBPC donation do not seem to be associated with rhG-CSF administration or the collection procedure, a lifelong follow-up of donors should be obligatory.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Cell Separation -
- Child -
- Cross-Sectional Studies -
- Female -
- Follow-Up Studies -
- Granulocyte Colony-Stimulating Factor - adverse effects Granulocyte Colony-Stimulating Factor - pharmacology
- Health Status -
- Hematopoietic Stem Cell Mobilization -
- Hematopoietic Stem Cells - physiology
- Humans -
- Male -
- Middle Aged -
- Quality of Life -
- Recombinant Proteins -
- Regeneration -
- Retrospective Studies -
- Tissue Donors - psychology
- Find related publications in this database (Keywords)
- allogeneic stem cell donation
- long-term follow-up
- quality of life