Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Worel, N; Greinix, H; Ackermann, J; Kaufmann, H; Urbauer, E; Höcker, P; Gisslinger, H; Lechner, K; Kalhs, P; Drach, J.
Deletion of chromosome 13q14 detected by fluorescence in situ hybridization has prognostic impact on survival after high-dose therapy in patients with multiple myeloma.
Ann Hematol. 2001; 80(6):345-348
Doi: 10.1007/s002770100296
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Interphase cytogenetic analysis of chromosome 13q14 was performed in 28 patients with multiple myeloma (MM) receiving high-dose therapy followed by autologous (n=24) or allogeneic (n=4) stem cell support. Eleven (39%) patients were found to have a deletion of chromosome 13q14. Response rates to high-dose therapy were independent of the chromosome 13 status, but patients with a deletion of 13q14 had a significantly shorter progression-free (p=0.001) and overall survival (p=0.012) than patients with normal chromosome 13q14. Our results indicate that high-dose therapy appears promising in patients with normal chromosome 13, whereas in patients with a deletion of 13q14 innovative therapeutic concepts are warranted.
- Find related publications in this database (using NLM MeSH Indexing)
- Actuarial Analysis -
- Adult -
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage
- Chromosomes, Human, Pair 13 - genetics
- Disease-Free Survival -
- Female -
- Gene Deletion -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- In Situ Hybridization, Fluorescence -
- Male -
- Middle Aged -
- Multiple Myeloma - diagnosis Multiple Myeloma - drug therapy Multiple Myeloma - genetics
- Prognosis -
- Retrospective Studies -
- Survival Rate -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- high-dose therapy in multiple myeloma
- FISH analysis
- deletion of chromosome 13q14