Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reiter, E; Rabitsch, W; Greinix, HT; Keil, F; Mitterbauer, G; Hinterberger, W; Haas, OA; Lechner, K; Kalhs, P.
Relapse of chronic myelogenous leukemia 12 years after allogeneic marrow transplantation: successful second transplantation with allogeneic peripheral blood progenitor cells.
Leuk Lymphoma. 2000; 40(1-2):215-218
Doi: 10.3109/10428190009054900
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- We report on a 31-year old female patient who relapsed with CML in blast crisis 12 years after a successful BMT for CML in chronic phase from her HLA-identical sister. Because of her good performance status and the long time elapsed since her first BMT, PBPC transplantation of the originial donor was planned. Therefore, the patient was conditioned with busulfan and cyclophosphamide and then received unmanipulated PBPCs from her sister. GVHD prophylaxis consisted of MTX and CsA. She had early engraftment but considerable hepatotoxicity which resolved after more than six months. Furthermore, she developed acute GVHD of the skin grade 2, which responded to corticosteroids. Fifteen months after second transplantation the patient is alive and well in molecular remission and without signs of chronic GVHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation - adverse effects
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
- Recurrence -
- Reoperation -
- Transplantation Conditioning - methods
- Transplantation, Isogeneic -
- Find related publications in this database (Keywords)
- allogeneic PBPC transplantation
- relapse
- BMT
- CML