Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gmeinhart, B; Hinterberger, W; Greinix, HT; Rabitsch, W; Kirnbauer, R; Reiter, E; Volc-Platzer, B.
Anaplastic squamous cell carcinoma (SCC) in a patient with chronic cutaneous graft-versus-host disease (GVHD).
Bone Marrow Transplant. 1999; 23(11):1197-1199
Doi: 10.1038/sj.bmt.1701772
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- We describe an allogeneic bone marrow (BM) recipient who developed aggressive, metastasizing squamous cell cancer (SCC) of the skin, and discuss possible risk factors in the development of this secondary solid tumor. The patient had been treated with cyclosporine (CsA), methyl-prednisolone and thalidomide for 3 years because of extensive de novo chronic cutaneous GVHD occurring 1 year after BMT. Ten years after BMT a locally invasive and metastasizing SCC occurred on the patient's neck, and diagnosis was confirmed by H&E histopathology and cytokeratin-immunohistochemistry. Analysis of genomic DNA did not reveal p53 mutations nor were HPV sequences detectable. Risk factors included conditioning for BMT with total body irradiation (TBI) and cyclophosphamide (Cy), immunosuppressive treatment for GVHD, and extensive exposure to UV radiation before and after BMT. Despite surgery and adjuvant chemotherapy with 5-fluorouracil (5-FU) the patient died 1 year after the diagnosis of SCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation - adverse effects
- Carcinoma, Squamous Cell - etiology
- Graft vs Host Disease - etiology
- Humans -
- Male -
- Neoplasms, Second Primary - etiology
- Skin Neoplasms - etiology
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- secondary malignancy
- squamous cell carcinoma
- GVHD
- immunosuppression