Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reiter, E; Kalhs, P; Keil, F; Rabitsch, W; Gisslinger, H; Mayer, G; Worel, N; Lechner, K; Greinix, HT.
Effect of high-dose melphalan and peripheral blood stem cell transplantation on renal function in patients with multiple myeloma and renal insufficiency: a case report and review of the literature.
Ann Hematol. 1999; 78(4):189-191
Doi: 10.1007/s002770050499
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Multiple myeloma with IgG-lambda monoclonal gammopathy and severe renal impairment with light-chain deposit disease was diagnosed in a 51-year-old man. Following conventional therapy with VAD (vincristine, adriamycin, dexamethasone) a partial remission was achieved. Peripheral blood stem cells (PBSC) were then collected following mobilization with cyclophosphamide and recombinant human granulocyte colony-stimulating factor and enriched for CD34-positive cells by immunoaffinity column. Fourteen months after diagnosis high-dose melphalan was given, followed by infusion of CD34-positive PBSC. Aside from mild oral mucositis and trigonitis, high-dose therapy was tolerated well. After he underwent PBSC transplantation his renal function improved, and the patient has been in in continuous complete remission for 1 year. Thus, high-dose chemotherapy can be safely administered to patients with multiple myeloma and severe renal impairment. Our findings confirm previous reports summarized in the current presentation.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents, Alkylating - administration & dosage
- Dose-Response Relationship, Drug -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Kidney - physiopathology
- Male -
- Melphalan - administration & dosage
- Middle Aged -
- Multiple Myeloma - complications Multiple Myeloma - physiopathology
- Renal Insufficiency - complications Renal Insufficiency - physiopathology
- Find related publications in this database (Keywords)
- multiple myeloma
- renal failure
- peripheral blood stem cell transplantation